This is a workflow that shows how to use Multi-Area conditioning with colour masking. It's a little unrefined, however it should give a good idea of how the overall process works.

Something important to consider is that for the blending to work well, a FULL area colour mask with a simplistic 'binding' prompt is requried that acts to keep the entire image somewhat coherent. If it's not used, each condtioned area has clear bounding that often shows clear boundaries.

Also, each colour conditioned area needs to have a little overlap with the other areas adjacent to it so that it encourages the sampler to blend seemlessly. The weighting of each condtioned area may need adjusting to get the blending to be smooth and it's impacted by the overall CFG strength of the sampler.

Each condtioned area compounds the sampling time.

Multi-regional Lora can be added using a similar method to the multi-area conditioning however each seperate lora has to be attached to a seperate sampler and significantly impacts the itteration time, so only use multi-regional lora if you really need to seperate the lora concept and the conditoning alone doesn't cut it.

The Tile Contronet helps keep the upsampling to retain the originally generated image, if tile controlnet isn't used, the upscaling has to have minimal denoising, which can cause clear seems for the condtioned area and also have surprinsing impacts on the upscaled image (sometimes this can be artistically cool though! especially when upscaling using a different SD or other image gen model).

The workflow also shows how controlnet and even IP Adapter can be applied to individual conditioned areas. You need to design the controlnet image to 'fit' within the masked controlnet area, as if that condtioned area is an image of it's own (in the context of applying controlnet). This definiate for Controlnet, I'm not entiraly sure about the IP Adapater masked regional application, although it appears to work in this example as I expected.

Have fun with it! It can be used to make some really cool complicated images with good prompting and imagination! <3

Happy Arting!